Friday, November 9, 2012

Next archbishop of Canterbury announcement Friday

FILE - In this Nov. 11, 2011 file photo, the Bishop of Durham, the Right Reverend Justin Welby. The next archbishop of Canterbury will be officially introduced Friday, Nov. 9, 2012 with the expectation that the new leader of the world?s Anglicans will be former oil company executive Jason Welby. (AP Photo/PA, Owen Humphreys, File) UNITED KINGDOM OUT, NO SALES, NO ARCHIVE

FILE - In this Nov. 11, 2011 file photo, the Bishop of Durham, the Right Reverend Justin Welby. The next archbishop of Canterbury will be officially introduced Friday, Nov. 9, 2012 with the expectation that the new leader of the world?s Anglicans will be former oil company executive Jason Welby. (AP Photo/PA, Owen Humphreys, File) UNITED KINGDOM OUT, NO SALES, NO ARCHIVE

(AP) ? The next archbishop of Canterbury will be officially introduced Friday, with the expectation that the new leader of the world's Anglicans will be former oil company executive Jason Welby.

Welby made an unusual mid-career shift from the oil industry to the clergy. He has said he faced conflicts between his beliefs and how companies acted ? and has made business ethics and standards part of his work.

"I don't believe in good human beings," Welby said in an interview with The Guardian newspaper in July. "But I believe you can have structures that make it easier to make the right choice or the wrong choice."

He has impeccable establishment credentials, having been schooled at Eton College and Cambridge University. His mother was a private secretary to Winston Churchill. But his father went to the United States during Prohibition and became a bootlegger, Welby was quoted as saying by the Mail on Sunday newspaper in July.

If British press reports are correct, Welby, 56, is set to become leader of the world's 77 million Anglicans.

Government and church officials declined Thursday to confirm speculation about the choice. But The Times and The Daily Telegraph have reported it will be Welby, and two British betting agencies stopped taking bets earlier this week after a flurry of wagers backing him.

Prime Minister David Cameron's office said the official announcement will be made Friday morning.

Welby declined to say 'yes' or 'no' to the swirl of speculation. "I am not able to comment, only Lambeth Palace can," he told reporters, referring to the church's headquarters.

The next archbishop will replace Rowan Williams, who is retiring after a turbulent decade dealing with the Anglican Communion's deep divisions about gay bishops and homosexuality.

Before he steps down, Williams is pressing hard to resolve a dispute over whether women can serve as bishops, the issue preoccupying the Church of England. A vote is set later this month by the church's governing General Synod.

Welby favors female bishops.

He serves as ethical adviser to the Association of Corporate Treasurers and was recently appointed to the Parliamentary Commission on Banking Standards, which is examining possible reforms of the industry.

Welby was praised Thursday by a U.S. colleague. Bishop Shannon Sherwood Johnston of Virginia, who has been working with Welby on a reconciliation project with dioceses in parts of West Africa, described him as a positive, friendly person.

"He's extremely amiable. He's a man of very deep faith and profound learning, but he is most approachable," Johnston said. "His diplomatic skills will be very important. "

Before seeking ordination, Welby worked six years for French oil company Elf Aquitaine and then as treasurer of exploration company Enterprise Oil in 1984.

His views on corporate responsibility, he has said, "came out of working in an extractive industry often in developing countries where ethical questions were very frequent."

"During my time there I came to realize there was a gap between what I thought, believed and felt was right in my non-work life and what went on at work."

In 1989, he resigned to study for the priesthood, but only after a struggle.

Welby has recalled being interviewed by a bishop who asked why he wanted to be a priest. "I said: 'I don't, but I can't get away from the feeling it is the right thing to do.'"

His dissertation in theological college was published under the title "Can companies sin?" He believes they can.

Following ordination in 1993 he was a parish priest for nine years before moving to Coventry Cathedral, as co-director of international ministry. In 2005, he became co-director of the cathedral's conflict reconciliation ministry in Africa, where he had experience in the oil industry.

"I have had to establish relationships with killers and with the families of their victims, with arms smugglers, corrupt officials and more," he once said.

In 2007 he was appointed dean of Liverpool Cathedral, Britain's largest church, and in November last year he was elevated to Durham, the fourth-ranking diocese in the church of England.

His business background still serves him well, Welby has said.

"Treasury teaches you to be decisive. Markets don't allow you to hang about and vacillate," he said in an interview in The Treasurer, the magazine of the Association of Corporate Treasurers. "And treasury teaches you about teamwork and working collaboratively. In treasury you are there to serve the company and the operating departments."

Welby and his wife Caroline have two sons and three daughters. Their first child, a 7-month-old girl, was killed in a traffic accident in 1983.

____

Rachel Zoll in New York contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-11-08-Britain-Archbishop%20of%20Canterbury/id-79a9773414914f8b948f6fbb10d0a720

Chad Johnson Twitter

Thursday, November 8, 2012

Obama victory infuriates Pakistani drone victims

Mohammad Hussain / AP

Supporters of cricket star-turned-politician Imran Khan's party raise their hands during a peace march protesting U.S. drone strikes on the outskirts of Tank, Pakistan, on Oct. 7.

By Reuters

ISLAMABAD, Pakistan - The roars celebrating the re-election of U.S. President Barack Obama on television give Mohammad Rehman Khan a searing headache, as years of grief and anger come rushing back.

The 28-year-old Pakistani accuses the president of robbing him of his father, three brothers and a nephew, all killed in a U.S. drone aircraft attack a month after Obama first took office.

"The same person who attacked my home has gotten re-elected," he told Reuters in the capital, Islamabad, where he fled after the attack on his village in South Waziristan, one of several ethnic Pashtun tribal areas on the Afghan border.


?

"Since yesterday, the pressure on my brain has increased. I remember all of the pain again."

The whole world was watching as America chose its president, and the general sentiment appeared to be a sigh of relief. NBC's Richard Engel reports.

World leaders welcome Obama's 2nd term - but many challenges loom

In his re-election campaign, Obama gave no indication he would halt or alter the drone program, which he embraced in his first term to kill al-Qaida and Taliban militants in Pakistan and Afghanistan without risking American lives.

Drone strikes are highly unpopular among many Pakistanis, who consider them a violation of sovereignty that cause unacceptable civilian casualties.

"Whenever he has a chance, Obama will bite Muslims like a snake. Look at how many people he has killed with drone attacks," said Haji Abdul Jabar, whose 23-year-old son was killed in such a bombing.

Analysts say anger over the unmanned aircraft may have helped the Taliban gain recruits, complicating efforts to stabilize the unruly border region between Pakistan and Afghanistan. That could also hinder Obama's plan to withdraw U.S. troops from Afghanistan in 2014.

A group of 32 American anti-drone activists will join a march to Pakistan's tribal areas, where U.S. strikes have killed thousands of people over the last eight years. NBC News Amna Nawaz spoke to some of them.

Americans ignore 'great risks,' travel to Pakistan to protest US drone strikes

Obama authorized nearly 300 drone strikes in Pakistan during his first four years in office, more than six times the number during the administration of George W. Bush, according to the New America Foundation policy institute.

Since 2004, a total of 337 U.S. drone strikes in Pakistan have killed between 1,908 and 3,225 people.

The institute estimates about 15 percent of those killed were non-militants, although that percentage has declined sharply to about 1-2 percent this year. Washington says drone strikes are very accurate and cause minimal civilian deaths.

The Pakistani government says tens of thousands of Pakistanis have been killed in the fight against militants. Many were civilians caught in suicide bombings. Others were killed by the Pakistani army.

In Pakistan's largest city, 'Old Glory' is flammable and profitable

Getting accurate data on casualties and the effects of drones is extremely difficult in the dangerous, remote and often inaccessible tribal areas. The Taliban often seal off the sites of strikes.

Muhammed Muheisen / AP

Images of daily life, political pursuits, religious rites and deadly violence.

While the aerial campaign has weakened al-Qaida, its ally, the Pakistani Taliban, remains a potent force despite a series of Pakistan army offensives against their strongholds in the northwest.

Seen as the biggest security threat to the U.S.-backed Pakistani government, that faction of the Taliban is blamed for many of the suicide bombings across Pakistan, and a number of high-profile attacks on military and police facilities.

For many Pakistanis, 'USA' means drones

"We are amazed that Obama has been re-elected. But for us there is no difference between Obama and Romney; both are enemies. And we will keep up our jihad and fight alongside our Afghan brothers to get the Americans out of Afghanistan," Pakistan Taliban spokesman Ehsanullah Ehsan said.

On Thursday, a suicide bomber rammed the gates of a military base in Pakistan's biggest city, Karachi, killing at least one soldier and wounding more than a dozen people.

Pakistan's 'Generation Y' battles to shape country's future

Pakistanis were largely indifferent in the run-up to Tuesday's election, expecting little change to the drone attacks regardless of whether Obama or Republican challenger Mitt Romney won.

"Any American, whether Obama or Mitt Romney, is cruel," Warshameen Jaan Haji, whose neighborhood was struck by a drone last week, told Reuters on the eve of the election. "I lost my wife in the drone attack and my children are injured. Whatever happens, it will be bad for Muslims."

Pakistani politician Imran Khan, a vocal critic of U.S. drone strikes, said he believed Obama stepped up the attacks in his first term so he wouldn't look weak on national security.

Despite security concerns, presidential candidate Imran khan leads an anti-drone rally, including 30 Americans, into Pakistan's badlands. Amna Nawaz reports.

"I think Obama essentially has an anti-war instinct," he told Reuters. "Without the worry of being re-elected, he will de-escalate the war, including the use of drones. This is positive."

Can social media propel 'rock star' politician Imran Khan to power?

But for Mohammad Khan, who is not related to the former cricketer, the damage is already done.

The February 2009 drone attack that destroyed his home left him as the main provider for 13 family members, forcing him to move to Islamabad and work with a real estate company.

"When the Sandy hurricane came, I thought that Allah would wipe away America," he said. "America just wants to take over the world."

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Source: http://worldnews.nbcnews.com/_news/2012/11/08/15015476-i-remember-all-of-the-pain-again-obama-victory-infuriates-pakistani-drone-victims?lite

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Wednesday, November 7, 2012

Factbox: Implications for different U.S. sectors post-election

(Reuters) - The result of Tuesday's U.S. presidential election will separate winners and losers across economic sectors and could determine which stocks will advance or decline in equity markets.

Below is a breakdown of the possible implications by sector of a victory by either Democratic President Barack Obama or his challenger, Republican Mitt Romney.

AN OBAMA VICTORY

* Alternative Energy: Obama has said he will continue to support development of renewable energy technologies such as solar and wind, but he will need the support of Congress to extend or renew tax breaks that have underpinned the growth of those industries.

* Chemicals: Producers are concerned that an Obama victory would mean a host of new regulations they say add undue costs and burden onto their businesses.

* Coal: The industry feels that tougher Environmental Protection Agency regulation under Obama has stifled the coal industry. Industry groups say coal plants that make up 3 percent of U.S. power generation capacity are due to be retired and there is no scope for new plants to be built under an Obama-run EPA.

* Finance: Financial reforms in the Dodd-Frank Act would likely be implemented more strictly for insurers and investment banks. Favorable tax policies for dividends and capital gains could change, affecting the profits of private equity firms.

* Healthcare: Hospitals and health insurers will benefit from the phased-in implementation of Obama's healthcare act, which requires most individuals to have health insurance.

* Rundown: Under a Democratic government the industries most likely to benefit include healthcare facilities and services, food and staples retailers, homebuilding and life sciences tools and services, according to a note from LPL Financial.

A ROMNEY VICTORY

* Chemicals: Producers are concerned that a Romney victory would mean that recent work to reauthorize existing chemical plant security standards would be voided by a plan to rework and re-legislate the standards.

* Coal: Romney signaled firm support for coal, along with natural gas and oil, on the campaign trail. He has said that under a Romney administration, the EPA would loosen industry regulations. But a victory may not be a clear one for coal. In 2003, as Massachusetts governor, Romney railed against a coal plant in the state as one that "kills people."

* Defense: A Romney victory would put an end to $500 billion in defense budget cuts scheduled to take effect early next year and would increase spending on weapons and warships.

* Healthcare: Romney has pledged to undo Obama's healthcare legislation on the first day of his presidency, but has not identified which parts of the legislation he would keep in place. Confusion over changing regulations would likely weigh on the shares of hospitals, insurers and drugmakers in the months to come.

* Technology: Giant tech companies such as Cisco Systems and Microsoft Corp, which each have more than $40 billion in cash overseas, could gain from a Romney victory since he would likely end or reduce the capital repatriation tax, according to UBS.

* Rundown: Under a Republican government the industries most likely to benefit include coal, oil and gas exploration and drilling, diversified financial services, specialty retailers and health insurers, according to a note from LPL Financial.

(Reporting by Rodrigo Campos and David Randall in New York; Editing by Jennifer Merritt and Andre Grenon)

Source: http://news.yahoo.com/factbox-implications-different-u-sectors-post-election-182955376.html

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Activists use peer pressure on voting history to urge Americans to vote (reuters)

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arnold palmer

Tuesday, November 6, 2012

Security through obscurity: How to cover your tracks online | CIO ...

Thinking about the bits of data you leave behind is a one-way ticket to paranoia. Your browser? Full of cookies. Your cellphone? A beacon broadcasting your location at every moment. Search engines track your every curiosity. Email services archive way too much. Those are just the obvious places we're aware of. Who knows what's going on inside those routers?

The truth is, worrying about the trail of digital footprints and digital dustballs filled with our digital DNA is not just for raving paranoids. Sure, some leaks like the subtle variations in power consumed by our computers are only exploitable by teams of geniuses with big budgets, but many of the simpler ones are already being abused by identity thieves, blackmail artists, spammers, or worse.

Sad news stories are changing how we work on the Web. Only a fool logs into their bank's website from a coffee shop wi-fi hub without using the best possible encryption. Anyone selling a computer on eBay will scrub the hard disk to remove all personal information. There are dozens of sound, preventative practices that we're slowly learning, and many aren't just smart precautions for individuals, but for anyone hoping to run a shipshape business. Sensitive data, corporate trade secrets, confidential business communications -- if you don't worry about these bits escaping, you may lose your job.

Learning how best to cover tracks online is fast becoming a business imperative. It's more than recognising that intelligent traffic encryption means not having to worry as much about securing routers, or that meaningful client-based encryption can build a translucent database that simplifies database management and security. Good privacy techniques for individuals create more secure environments, as a single weak link can be fatal. Learning how to cover the tracks we leave online is a prudent tool for defending us all.

Each of the following techniques for protecting personal information can help reduce the risk of at least some of the bytes flowing over the internet. They aren't perfect. Unanticipated cracks, even when all of these techniques are used together, always arise. Still, they're like deadbolt locks, car alarms, and other security measures: tools that provide enough protection to encourage the bad guys to go elsewhere.

Online privacy technique No. 1: Cookie management
The search engines and advertising companies that track our moves online argue they have our best interests at heart. While not boring us with the wrong ads may be a noble goal, that doesn't mean the relentless tracking of our online activities won't be used for the wrong reasons by insiders or websites with less esteemed ideals.

The standard mechanism for online tracking is to store cookies in your browser. Every time you return to a website, your browser silently sends the cookies back to the server, which then links you with your previous visits. These little bits of personalised information stick around for a long time unless you program your browser to delete them.

Most browsers have adequate tools for paging through cookies, reading their values, and deleting specific cookies. Cleaning these out from time to time can be helpful, although the ad companies have grown quite good at putting out new cookies and linking the new results with the old.?Close 'n Forget, a Firefox extension, deletes all cookies when you close the tab associated with a site.

Standard cookies are just the beginning. Some ad companies have worked hard on burrowing deeper into the operating system. The Firefox extension?BetterPrivacy, for example, will nab the "supercookies" stored by the Flash plug-in. The standard browser interface doesn't know that these supercookies are there, and you can delete them only with an extension like this or by working directly with the Flash plug-in.

There are still other tricks for sticking information in a local computer.?Ghostery, another Firefox extension, watches the data coming from a website, flags some of the most common techniques (like installing single-pixel images), and lets you reverse the effects.

Online privacy technique No. 2: Tor
One of the simplest ways to track your machine is through your IP address, the number the Internet uses like a phone number so that your requests for data can find their way back to your machine. IP addresses can change on some systems, but they're often fairly static, allowing malware to track your usage.

One well-known tool for avoiding this type of tracking is called Tor, an acronym for "The Onion Router." The project, developed by the Office of Naval Research, creates a self-healing, encrypted supernetwork on top of the Internet. When your machine starts up a connection, the Tor network plots a path through N different intermediate nodes in the Tor subnet. Your requests for web pages follow this path through the N nodes. The requests are encrypted N times, and each node along the path strips off a layer of encryption like an onion with each hop through the network.

The last machine in the path then submits your request as if it were its own. When the answer comes back, the last machine acting as a proxy encrypts the Web page N times and sends it back through the same path to you. Each machine in the chain only knows the node before it and the node after it. Everything else is an encrypted mystery. This mystery protects you and the machine at the other end. You don't know the machine and the machine doesn't know you, but everyone along the chain just trusts the Tor network.

While the machine acting as your proxy at the other end of the path may not know you, it could still track the actions of the user. It may not know who you are, but it will know what data you're sending out onto the web. Your requests for web pages are completely decrypted by the time they get to the other end of the path because the final machine in the chain must be able to act as your proxy. Each of the N layers was stripped away until they're all gone. Your requests and the answers they bring are easy to read as they come by. For this reason, you might consider adding more encryption if you're using Tor to access personal information like email.

There are a number of ways to use Tor that range in complexity from compiling the code yourself to downloading a tool. One popular option is downloading?the Torbutton Bundle, a modified version of Firefox with a plug-in that makes it possible to turn Tor on or off while using the browser; with it, using Tor is as simple as browsing the web. If you need to access the internet independently from Firefox, you may be able to get the proxy to work on its own.

Online privacy technique No. 3: SSL
One of the easiest mechanisms for protecting your content is the encrypted SSL connection. If you're interacting with a website with the prefix "https," the information you're exchanging is probably being encrypted with sophisticated algorithms. Many of the better email providers like Gmail will now encourage you to use an HTTPS connection for your privacy by switching your browser over to the more secure level if at all possible.

An SSL connection, if set up correctly, scrambles the data you post to a website and the data you get back. If you're reading or sending email, the SSL connection will hide your bits from prying eyes hiding in any of the computers or routers between you and the website. If you're going through a public wi-fi site, it makes sense to use SSL to stop the site or anyone using it from reading the bits you're sending back and forth.

SSL only protects the information as it travels between your computer and the distant website, but it doesn't control what the website does with it. If you're reading your email with your web browser, the SSL encryption will block any router between your computer and the email website, but it won't stop anyone with access to the mail at the destination from reading it after it arrives. That's how your free web email service can read your email to tailor the ads you'll see while protecting it from anyone else. The web email service sees your email in the clear.

There are a number of complicated techniques for subverting SSL connections, such as poisoning the certificate authentication process, but most of them are beyond the average eavesdropper. If you're using a local coffee shop's wi-fi, SSL will probably stop the guy in the back room from reading what you're doing, but it may not block the most determined attacker.

Online privacy technique No. 4: Encrypted messages
While Tor will hide your IP address and SSL will protect your bits from the prying eyes of network bots, only encrypted mail can protect your message until it arrives. The encryption algorithm scrambles the message, and it's bundled as a string of what looks like random characters. This package travels directly to the recipient, who should be the only one who has the password for decrypting it.

Encryption software is more complicated to use and far less straightforward than SSL. Both sides must be running compatible software, and both must be ready to create the right keys and share them. The technology is not too complicated, but it requires much more active work.

There's also a wide range in quality of encryption packages. Some are simpler to use, which often makes for more weaknesses, and only the best can resist a more determined adversary. Unfortunately, cryptography is a rapidly evolving discipline that requires a deep knowledge of mathematics. Understanding the domain and making a decision about security can require a doctorate and years of experience. Despite the problems and limitations, even the worst programs are often strong enough to resist the average eavesdropper - like someone abusing the system admin's power to read email.

Online privacy technique No. 5: Translucent databases
The typical website or database is a one-stop target for information thieves because all the information is stored in the clear. The traditional solution is to use strong passwords to create a wall or fortress around this data, but once anyone gets past the wall, the data is easy to access.

Another technique is to only store encrypted data and ensure all the encryption is done at the client before it is shipped across the Internet. Sites like these can often provide most of the same services as traditional websites or databases while offering much better guarantees against information leakage.

A number of techniques for applying this solution are described in my book "Translucent Databases." Many databases offer other encryption tools that can provide some or all of the benefits, and it's easy to add other encryption to the Web clients.

In the best examples, the encryption is used to obscure only the sensitive data, leaving the rest in the clear. This makes it possible to use the nonpersonal information for statistical analysis and data-mining algorithms.

Online privacy technique No. 6: Steganography?
One of the most elusive and beguiling techniques is steganography, a term generally applied to the process of hiding a message so that it can't be found. Traditional encryption locks the data in a safe; steganography makes the safe disappear. To be more accurate, it disguises the safe to look like something innocuous, such as a houseplant or a cat.

The most common solutions involve changing some small part of the file in a way it won't be noticed. A single bit of a message, for instance, can be hidden in a single pixel by arranging the parity of the red and green components. If they're both even or both odd, then the pixel carries the message of 0. If one is even and one is odd, then it's a 1. To be more concrete, imagine a pixel with red, green and blue values of 128, 129, and 255. The red value is even, but the green value is odd, meaning the pixel is carrying the message of 1.

A short, one-bit message can be hidden by taking a file, agreeing upon a pixel, and making a small change in either the red or green value so that the pixel carries the right message. A one-bit change will be tiny and almost certainly not visible to the human, but a computer algorithm looking in the right place will be able to find it.

If this technique is repeated long enough, any amount of data can be hidden. An image with 12 megapixels can store a message with 12Mb, or 1.5MB, without changing any pixel by more than one unit of red or green. Judicious use of compression can improve this dramatically. A large message like this article can be snuck into the corners of an average photo floating around the internet.

Tweaking pixels is just one of the ways that messages can be inserted in different locations. There are dozens of methods to apply this approach - for example, replacing words with synonyms or artfully inserting slight typographical mistakes into an article. Is that a misspelling or a secret message? All rely on inserting small, unnoticeable changes.

Steganography is not perfect or guaranteed to avoid detection. While the subtle changes to values like the red and green component may not be visible to the naked eye, clever algorithms can sometimes find the message. A number of statistical approaches can flag files with hidden messages by looking for patterns left behind by sloppy changes. The glare off of glass or chrome in a picture is usually stuffed with pixels filled with the maximum amount of red, green, and blue. If a significant number of these are just one unit less than the maximum, there's a good chance that a steganographic algorithm made changes.

These detection algorithms also have limits, and there are a number of sophisticated approaches for making the hidden messages harder to find. The scientists working on detection are playing a cat-and-mouse game with the scientists looking for better ways to hide the data.

Source: http://cio.co.nz/cio.nsf/tech/security-through-obscurity-how-to-cover-your-tracks-online

leprosy

Monday, October 29, 2012

European Entrepreneurship Foundation ? ? David Szabo ...

Seedcamp was camping in Budapest this week. If you?re a number person, you?ll love their number pitch: 200 applications, 20 selected teams and 2 investments. I had the pleasure to mentor 4 of the 20 startups. These teams came from Budapest, Bucharest, Brescia and Nis. It was a diverse event, carefully selected, quality fruit, strong mentors and a number of very serious investors from Central and Western Europe. The event was hosted in the Corvinus University, a prestigious location, and Peter Zaboji, the organiser amazed us again.

?European entrepreneurial investor of the year?? Klaus Hommels (early investor in Skype, Facebook, Xing and Spotify) has been on stage as key note speaker, mentored teams and was available for chit-chat ? wow ? I say wow because he wasn?t just wondering around in Budapest as a tourist, but he flew here as a friend of Peter (sits on EEF?s Advisory Board) and shared what was in his mind with the Seedcamp guys ? us. I still remember the shock in the room when he has spoken to one of the teams on stage and (I try to quote him) kindly said:

?Your target market is about 10,000 enterprises,

So, if you work super-hard and do your best ever job in the next 4 years,

You?ll hit $ 6 m in revenue, ?Jesus!

If you don?t think big, you?ll never get big?.

Surely shocking and so far away from the Central European reality; I was so glad to see this happening with my own eyes.

Taking it all to the next level, Peter invited us all to his E Liquidity event, sponsored by KoWerk. Here, about 150 people met and mixed, exchanged ideas and business cards or just simply had fun. In case you haven?t been to Peter?s events, he?s doing a great job of filling his friends? calendars with quality events like this, slowly but steadily building a hub or better ? a family ? of entrepreneurs, wannabees and enthusiasts in the region. There are people who drive for hours from Cluj, Ljubjana, Prague or Bratislava to drop by for a few hours, and then drive back home. I look around at these events and can?t believe that this is happening in Budapest. Or in other words, I can?t believe that I?m in Budapest. Something great has started, quality stuff and it?s growing in impact. Once in a fortnight, there?s announcement of $1 m investment into a startup (graduated at EEF?s accelerator course) who has been around, just drinking ros? and chatting on one of these events last week. It?s a true elite club, always quality, always productive and always fun.

Where is all this going? I haven?t a clue. Klaus Hommels said in his pitch something that I see as a steering factor in the European entrepreneur ecosystem though. He compared Europe, China and the USA in terms of startup revenue and average investment size in the light of GDP per capita. His tarot showed Europe and China somewhat in the same range, while they stood by the US column chart like a parking mall by a skyscraper. It?s obvious that startups make their big money in the US and Europe is purely the talent sourcing department ? and you know what? I?m very proud of this. The world has changed and I?m glad to see this rather special part of Europe to open and offer these amazing opportunities to the best talent ? to let them shine where there?s need for sunshine.

Source: http://www.europreneurs.org/2012/10/european-vc-ecosystem-visiting-budapest/

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Wednesday, October 24, 2012

Aggressive brain tumors can originate from a range of nervous system cells

ScienceDaily (Oct. 22, 2012) ? Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 17 in Science, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

GBM is one of the most devastating brain tumors that can affect humans. Despite progress in genetic analysis and classification, the prognosis of these tumors remains poor, with most patients dying within one to two years of diagnosis. The Salk researcher's findings offer an explanation for the recurrence of GBM following treatment and suggest potential new targets to treat these deadly brain tumors.

"One of the reasons for the lack of clinical advances in GBMs has been the insufficient understanding of the underlying mechanisms by which these tumors originate and progress," says Inder Verma, a professor in Salk's Laboratory of Genetics and the Irwin and Joan Jacobs Chair in Exemplary Life Science.

To better understand this process, Verma's team harnessed the power of modified viruses, called lentiviruses, to disable powerful tumor suppressor genes that regulate the growth of cells and inhibit the development of tumors. With these tumor suppressors deactivated, cancerous cells are given free rein to grow out of control.

To do that, Verma and his colleagues attached small RNA molecules, known as short hairpin RNAs, to the modified viruses and injected them directly into very few cells in the brains of genetically engineered mice that express an enzyme known as CRE specifically in neurons, astrocytes or neural stem cells. The modified viruses target two genes -- -neurofibromatosis 1 (NF1) and p53 -- -that, when mutated, are implicated in severe gliomas like GBM. Using sophisticated analytical techniques, they discovered that neurons genetically converted by the lentiviruses that also produce green fluorescent protein (GFP) as a marker to track the progression of tumors are capable of forming malignant gliomas.

Because the origin of glioblastomas from neurons has not been previously reported, the Salk scientists provided further evidence that mature neurons can be transformed by these oncogenes by isolating cortical neurons from genetically engineered mice and transducing them with one of the lentiviruses. The neurons that were transplanted back into the mice developed the same tumors as the ones in the laboratory.

"Our findings," says lead author Dinorah Friedmann-Morvinski, a postdoctoral researcher in the Laboratory of Genetics, "suggest that, when two critical genes -- -NF-1 and p53 -- -are disabled, mature, differentiated cells acquire the capacity to reprogram [dedifferentiate] to a neuroprogenitor cell-like state, which can not only maintain their plasticity, but also give rise to the variety of cells observed in malignant gliomas."

If scientists can block the process of dedifferentiation or proliferation of dedifferentiated neuroprogenitor cells, they may be able to stop tumor progression. That's important in an aggressive disease like GBM because of its high rate of recurrence.

"Our results offer an explanation of recurrence of gliomas following treatment," says Verma, "because any tumor cell that is not eradicated can continue to proliferate and induce tumor formation, thereby perpetuating the cycle of continuous cell replication to form malignant gliomas."

The scientists say the tumors in their mouse model are similar to GBMs that affect humans. Because they have the same pathology and characteristic genetic signature, scientists can study potential therapies in mice that should, theoretically, work in humans. While they may not eradicate GBM, these therapies may slow the progression of the disease and improve patients' quality of life.

Other researchers on the study were Eugene Ke, Yasushi Soda, Tomotoshi Marumoto and Oded Singer of the Salk Institute; and Eric Bushong and Mark Ellisman of the University of California, San Diego.

The work was supported by the National Institutes of Health, Ipsen/Biomeasure, the Leona M. and Harry B. Helmsley Charitable Trust, the H.N. and Frances C. Berger Foundation, and the National Center for Research Resources.

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The above story is reprinted from materials provided by Salk Institute for Biological Studies, via Newswise.

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Journal Reference:

  1. D. Friedmann-Morvinski, E. A. Bushong, E. Ke, Y. Soda, T. Marumoto, O. Singer, M. H. Ellisman, I. M. Verma. Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice. Science, 2012; DOI: 10.1126/science.1226929

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/FmwsERG8M9g/121022162341.htm

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