European Entrepreneurship Foundation ? ? David Szabo ...

Seedcamp was camping in Budapest this week. If you?re a number person, you?ll love their number pitch: 200 applications, 20 selected teams and 2 investments. I had the pleasure to mentor 4 of the 20 startups. These teams came from Budapest, Bucharest, Brescia and Nis. It was a diverse event, carefully selected, quality fruit, strong mentors and a number of very serious investors from Central and Western Europe. The event was hosted in the Corvinus University, a prestigious location, and Peter Zaboji, the organiser amazed us again.

?European entrepreneurial investor of the year?? Klaus Hommels (early investor in Skype, Facebook, Xing and Spotify) has been on stage as key note speaker, mentored teams and was available for chit-chat ? wow ? I say wow because he wasn?t just wondering around in Budapest as a tourist, but he flew here as a friend of Peter (sits on EEF?s Advisory Board) and shared what was in his mind with the Seedcamp guys ? us. I still remember the shock in the room when he has spoken to one of the teams on stage and (I try to quote him) kindly said:

?Your target market is about 10,000 enterprises,

So, if you work super-hard and do your best ever job in the next 4 years,

You?ll hit $ 6 m in revenue, ?Jesus!

If you don?t think big, you?ll never get big?.

Surely shocking and so far away from the Central European reality; I was so glad to see this happening with my own eyes.

Taking it all to the next level, Peter invited us all to his E Liquidity event, sponsored by KoWerk. Here, about 150 people met and mixed, exchanged ideas and business cards or just simply had fun. In case you haven?t been to Peter?s events, he?s doing a great job of filling his friends? calendars with quality events like this, slowly but steadily building a hub or better ? a family ? of entrepreneurs, wannabees and enthusiasts in the region. There are people who drive for hours from Cluj, Ljubjana, Prague or Bratislava to drop by for a few hours, and then drive back home. I look around at these events and can?t believe that this is happening in Budapest. Or in other words, I can?t believe that I?m in Budapest. Something great has started, quality stuff and it?s growing in impact. Once in a fortnight, there?s announcement of $1 m investment into a startup (graduated at EEF?s accelerator course) who has been around, just drinking ros? and chatting on one of these events last week. It?s a true elite club, always quality, always productive and always fun.

Where is all this going? I haven?t a clue. Klaus Hommels said in his pitch something that I see as a steering factor in the European entrepreneur ecosystem though. He compared Europe, China and the USA in terms of startup revenue and average investment size in the light of GDP per capita. His tarot showed Europe and China somewhat in the same range, while they stood by the US column chart like a parking mall by a skyscraper. It?s obvious that startups make their big money in the US and Europe is purely the talent sourcing department ? and you know what? I?m very proud of this. The world has changed and I?m glad to see this rather special part of Europe to open and offer these amazing opportunities to the best talent ? to let them shine where there?s need for sunshine.

Source: http://www.europreneurs.org/2012/10/european-vc-ecosystem-visiting-budapest/

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Aggressive brain tumors can originate from a range of nervous system cells

ScienceDaily (Oct. 22, 2012) ? Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 17 in Science, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

GBM is one of the most devastating brain tumors that can affect humans. Despite progress in genetic analysis and classification, the prognosis of these tumors remains poor, with most patients dying within one to two years of diagnosis. The Salk researcher's findings offer an explanation for the recurrence of GBM following treatment and suggest potential new targets to treat these deadly brain tumors.

"One of the reasons for the lack of clinical advances in GBMs has been the insufficient understanding of the underlying mechanisms by which these tumors originate and progress," says Inder Verma, a professor in Salk's Laboratory of Genetics and the Irwin and Joan Jacobs Chair in Exemplary Life Science.

To better understand this process, Verma's team harnessed the power of modified viruses, called lentiviruses, to disable powerful tumor suppressor genes that regulate the growth of cells and inhibit the development of tumors. With these tumor suppressors deactivated, cancerous cells are given free rein to grow out of control.

To do that, Verma and his colleagues attached small RNA molecules, known as short hairpin RNAs, to the modified viruses and injected them directly into very few cells in the brains of genetically engineered mice that express an enzyme known as CRE specifically in neurons, astrocytes or neural stem cells. The modified viruses target two genes -- -neurofibromatosis 1 (NF1) and p53 -- -that, when mutated, are implicated in severe gliomas like GBM. Using sophisticated analytical techniques, they discovered that neurons genetically converted by the lentiviruses that also produce green fluorescent protein (GFP) as a marker to track the progression of tumors are capable of forming malignant gliomas.

Because the origin of glioblastomas from neurons has not been previously reported, the Salk scientists provided further evidence that mature neurons can be transformed by these oncogenes by isolating cortical neurons from genetically engineered mice and transducing them with one of the lentiviruses. The neurons that were transplanted back into the mice developed the same tumors as the ones in the laboratory.

"Our findings," says lead author Dinorah Friedmann-Morvinski, a postdoctoral researcher in the Laboratory of Genetics, "suggest that, when two critical genes -- -NF-1 and p53 -- -are disabled, mature, differentiated cells acquire the capacity to reprogram [dedifferentiate] to a neuroprogenitor cell-like state, which can not only maintain their plasticity, but also give rise to the variety of cells observed in malignant gliomas."

If scientists can block the process of dedifferentiation or proliferation of dedifferentiated neuroprogenitor cells, they may be able to stop tumor progression. That's important in an aggressive disease like GBM because of its high rate of recurrence.

"Our results offer an explanation of recurrence of gliomas following treatment," says Verma, "because any tumor cell that is not eradicated can continue to proliferate and induce tumor formation, thereby perpetuating the cycle of continuous cell replication to form malignant gliomas."

The scientists say the tumors in their mouse model are similar to GBMs that affect humans. Because they have the same pathology and characteristic genetic signature, scientists can study potential therapies in mice that should, theoretically, work in humans. While they may not eradicate GBM, these therapies may slow the progression of the disease and improve patients' quality of life.

Other researchers on the study were Eugene Ke, Yasushi Soda, Tomotoshi Marumoto and Oded Singer of the Salk Institute; and Eric Bushong and Mark Ellisman of the University of California, San Diego.

The work was supported by the National Institutes of Health, Ipsen/Biomeasure, the Leona M. and Harry B. Helmsley Charitable Trust, the H.N. and Frances C. Berger Foundation, and the National Center for Research Resources.

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Story Source:

The above story is reprinted from materials provided by Salk Institute for Biological Studies, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. D. Friedmann-Morvinski, E. A. Bushong, E. Ke, Y. Soda, T. Marumoto, O. Singer, M. H. Ellisman, I. M. Verma. Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice. Science, 2012; DOI: 10.1126/science.1226929

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/FmwsERG8M9g/121022162341.htm

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Google Stoops to a New Low! | Internet Marketing Secrets, Affiliate ...

I must say when I saw what I?m about to show you in this post I had to check it twice as I didn?t quite believe what I was seeing at first, but sure enough Google has stooped to a new low today in their never quenching thirst for more profit. I can?t confirm that this has been rolled out across the world, but it is happening where I live in New Zealand anyway.

Before I show you this I first want to lay down a little background. We all know that Google makes their money when people click their ads listed on a Google results pages and on other websites that are opting into the Adsense program. So obviously Google?s agenda is to get as many of these ads clicked as possible.

However stop for just a moment and remember what Google is useful for and why it has become such a popular tool for people to use in the first place. Google is a search engine, not a giant advertising billboard, let?s get that straight to start with. People use Google as a gateway to the internet, and Google is supposed to be showing a list of the most relevant websites related to a user?s search queries.

This all sounds well and good, what a great service, Google makes it easy for us to find websites right?well sort of, but over the years Google has taken advantage of their popularity and slowly but surely are moving towards being one giant advertising billboard and that?s it!!

What Happened to the Organic Listing?

Yes the organic listings, the websites that Google lists that DO NOT pay Google to be there. The ones that do SEO (search engine optimization) and get ranked on the front page of Google, what did happen to them? The way Google is going you might have to scroll to page 3 to find an organic listing soon.

Let?s take a look at a typical Google results page below that I see when I search in Google, so you can see where I?m going with this. This might not be the same for you, as possible Google is testing this out in some countries, New Zealand where I live being the perfect test place.

So you can see from that image that above the fold of the page now 95% of the real estate is taken up by NON ORGANIC listings. Google has now added an extra listing for ?Searches related to KEYWORD? just below where the Google Ads finish, thus pushing the organic results even further down the page.

When people click on these related results, it will load a new Google page which will of course show more Google Ads, and give Google another chance to get them clicked. This is just another aggressive trick from Google to stop people from visiting websites that are not Ads.

This is not the first time they have done dirty tricks like this, in fact Google is slowly but surely doing more and more of these cunning techniques. Don?t believe me? Well think back to 12 months ago when the background color of ALL ADS where a pink color that was obvious, so searches new if they were clicking on an ad. Well Google went from obvious pink to a light pink that was hard to distinguish without tilting your screen, to now being WHITE so you can?t tell at all!

But there?s more, Google use to make it very obvious what listings were ads by telling you, as they were say ?Ads by Google?, but I guess that was being too helpful so now they just have the words ?Ads? and I wouldn?t be surprized if they remove even that soon.

What amazes me is that the FTC (Federal Trade Commission) comes down on affiliate sites who don?t make it obvious that they make a commission from links on their sites, but they let Google continue down this aggressive and somewhat deceptive path of advertising.

Do Know Evil?.As Google Do Plenty For Us All

I get sick and tired of listening to garbage from Matt Cutts at Google telling us all to be transparent and put up QUALITY sites for the user experience when I see Google turn around and pull moves like this latest stunt.

One of Google Panda?s penalties was for sites that have too much advertising above the fold!!!!!! Can you see the irony in this, when a Google results page is essentially nothing more than one giant ad, as they push the organic results below the fold.

Google?s motto is ?do no evil? yeah right, you have to be kidding me, Google is shown quite clearly that they have no interest in helping people find the best website that meets their search query and instead want to show you the results that make them the most money.

Summary

I hope this latest move by Google annoys you as much as it has me. I would love to hear from you all below in the comments. However like I said Google might not have rolled this out globally yet, so you might not see it when you use Google, but I can assure you that it is there when I use Google, so something is going on.

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Source: http://mattsmarketingblog.com/seo/google-stoops-to-a-new-low/

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In town seen as pro-Qaddafi, settling of scores shifts into standoff with government

While Bani Walid is suspected of harboring Qaddafi loyalists, resident complain they are unfairly persecuted. Fighting around the town has underscored the need for Libya's government to establish its authority.

By John Thorne,?Correspondent / October 20, 2012

A year to the day after Muammar Qaddafi was killed, a town long tarred as sympathetic to him is under attack by government-aligned militias in what many Libyans describe as settling unfinished business.
?
Libya?s government wants the town of Bani Walid, southeast of Tripoli, to hand over suspects accused of kidnapping a militiaman from the city of Misurata credited with having helped run Qaddafi down last year. In recent days a tense standoff has turned violent.
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For many in Bani Walid, the affair confirms their longstanding complaints of persecution in post-Qaddafi Libya. For the country?s new leaders, it is yet another test of their ability to assert their authority while managing the militias upon whom Tripoli relies to help keep order.

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?The campaign to liberate the country has not been fully completed,? said Mohamed Magarief, president of Libya?s congress, speaking late yesterday on Libyan TV and quoted by Reuters. He said delays in integrating militias into state security forces have led to a degree of ?chaos? in Libya.

?And the chaos has lured others to kidnappings, stealing, and to create non-legitimate prisons,? Mr. Magarief said. ?What has happened in Bani Walid in the last few days falls under this?. it has become a safe haven for a large number of those who are outside of the law.?

In an apparently separate incident, Libyan forces arrested Qaddafi?s former spokesman, Moussa Ibrahim, today in the city of Tarhouna, south of Tripoli, said a statement from the prime minister?s office cited by Reuters. Known for his unswerving defense of Qaddafi?s regime to foreign media last year, Ibrahim disappeared as that regime collapsed in August 2011.

Doubts about Bani Walid's loyalties

The current trouble in Bani Walid began last month when Omran Shaban, a Misuratan militiaman who reportedly found Qaddafi hiding in a drain culvert last year, died from injuries his family say occurred during two months of captivity in Bani Walid.

For many Libyans, Shaban?s fate confirmed suspicions that Bani Walid harbors Qaddafi loyalists. The town largely stayed out of last year?s revolution and fought back against attempts to enter it by rebel forces amid rumors that Saif al-Islam Qaddafi was hiding there.

As talks over surrendering Shaban?s alleged kidnappers got under way, pro-government brigades mainly from Misurata ringed Bani Walid. Many in the town say it has suffered undue persecution since Qaddafi?s fall.

?We?re not for Qaddafi,? says Meftah Jabbara, a law professor in Bani Walid who took part in the recent talks. ?We?re for Libya. We?re not living in the past.?

According to Mr. Jabbara, talks broke down after Misurata refused to release around 150 Bani Walid residents he said were detained there. A government deadline on surrendering Shaban?s alleged kidnappers came and went, and skirmishes broke out.

Barring potential last-ditch mediation by leaders from eastern Libya who might be trusted in Bani Walid, further negotiation with Tripoli and Misurata is all but futile, says Jabbara.

?When they kill your children and your old men, how is dialogue possible?? he says. ?Our men are ready to die, and if so they will die as martyrs.?

Meanwhile, it?s unclear how firmly leaders control pro-government militias meant to act as government muscle. Today, Magarief today condemned the recent escalation in fighting at Bani Walid in a statement cited by Libya?s Libya Herald newspaper.

At least a dozen people have been reported killed so far, with numbers hard to verify. Greater suffering is feared if fighting continues, says Soaade Messoudi, a spokeswomen in Tripoli for the International Committee of the Red Cross.

The organization has twice visited Bani Walid in the last two weeks to deliver medical aid, she says. ?We are urging all the parties to act with caution and respect human lives, medical staff, and medical facilities.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/AHZXR_hXaQ4/In-town-seen-as-pro-Qaddafi-settling-of-scores-shifts-into-standoff-with-government

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